Association of vascular invasion with increased mortality in patients with minimally invasive follicular thyroid carcinoma but not widely invasive follicular thyroid carcinoma.
نویسندگان
چکیده
BACKGROUND The association of vascular invasion with tumor aggressiveness and poor prognosis in follicular thyroid carcinoma (FTC) remains controversial. METHODS We reviewed medical records of 204 patients with histologically confirmed FTC. RESULTS The disease-specific survival rates at 5 and 10 years were 94% and 85%, respectively. Using Cox proportional hazard model, the extent of invasiveness and the frequency of distant metastasis were found to be independent prognostic factors for survival in all patients with FTC. When we performed individual analyses stratified by the extent of invasiveness, vascular invasion was an independent predictor of disease-specific survival in minimally invasive FTC, but that did not independently affect survival in widely invasive FTC. CONCLUSION This study suggests that vascular invasion is associated with aggressive features of FTC and independently influences outcomes in minimally invasive FTC. For patients aged <45 years with minimally invasive FTC without vascular invasion, thyroid lobectomy alone may be adequate.
منابع مشابه
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience
Follicular thyroid carcinoma classically accounts for 10-32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed. The medical records of all patients who underwent thyroidectomy from October 1998 to April 2...
متن کاملPrognostic significance of patient age in minimally and widely invasive follicular thyroid carcinoma: investigation of three age groups.
Follicular thyroid carcinoma (FTC) is the second most common malignancy arising from follicular cells. It is classified into two categories based on the degree of invasion: widely and minimally invasive FTC. Here we focused on the prognostic value of patient age in FTC. We enrolled 292 minimally invasive and 79 widely invasive FTC patients who underwent initial surgery between 1983 and 2007. We...
متن کاملMinimally invasive follicular thyroid carcinoma.
Infiltration of the capsule, vascular invasion, and/or neoplastic extension into the adjacent parenchyma are regarded as prerequisites for the diagnosis of follicular carcinoma. In modern practice, most of these tumors fall into the category of follicular carcinoma, minimally invasive (FCMI) characterized by evidence of limited capsular or vascular invasion with an excellent long-term prognosis...
متن کاملSolitary skull metastasis from follicular thyroid carcinoma: a case report
Introduction: Follicular thyroid carcinoma (FTC) is the second most common malignant form of thyroid cancers. FTC is more common in women with a peak incidence in the fifth and sixth decades of life. Invasion into blood vessels may lead to distant metastasis to bone, lung, liver or elsewhere. FTC rarely manifests itself as a distant metastatic lesion, especially as solitary metastasis. Case r...
متن کاملClassification of thyroid follicular cell tumors: with special reference to borderline lesions.
We propose a new classification of thyroid follicular cell tumors which is correlated with patient's prognosis. It is unique as to two new categories: borderline malignancy between benign and malignant, and moderately differentiated adenocarcinoma (MDA) as a differentiation classification to stratify tumor aggressiveness. As to diagnostic criteria, we recommend invasiveness (capsular and vasc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Head & neck
دوره 36 12 شماره
صفحات -
تاریخ انتشار 2014